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Although an effect of accutane isotretinoin on bone loss is not established, physicians should use caution when prescribing accutane isotretinoin to patients with a genetic predisposition for age-related osteoporosis, a history of childhood osteoporosis conditions, osteomalacia, or other disorders of bone metabolism.

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Sinc isottinoin is dsignd to tat sv acn, it has a visibl ct on th skin. Th mdication can b vy ctiv in tating sv acn bcaus it tagts:

Isottinoin must not b usd by mal patints who a o may bcom pgnant. Th is an xtmly high isk that sv bith dcts will sult i pgnancy occus whil taking isottinoin. I pgnancy dos occu duing tatmnt o a mal patint who is taking isottinoin, isottinoin must b discontinud immdiatly, and sh should b d to an Obsttician-Gyncologist xpincd in poductiv toxicity o uth valuation and counsling. Bcaus o isottinoin’s tatognicity, it is appovd o makting only und a spcial stictd distibution pogam calld iPLDG(TM). Th pscib, patint, and phamacy must b gistd and mt all o th quimnts o iPLDG bo distibution .

Bon o joint pain buning, dnss, itching, o oth signs o y inlammation diiculty with moving nosblds scaling, dnss, buning, pain, o oth signs o inlammation o th lips skin inction o ash.

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