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Estrogen treatment of prepubertal children also induces premature breast development and vaginal cornificationand may potentially induce vaginal bleeding in girlsIn boysestrogen treatment may modify the normal pubertal processAll other physiological and adverse reactions shown to be associated with estrogen treatment of adults could potentially occur in the pediatric populationincluding thromboembolic disorders and growth stimulation of certain tumorsThereforeestrogens should only be administered to pediatric patients when clearly indicated and the lowest effective dose should always be utilized.

Unusual vaginal bleeding can be a warning sign of cancer of the uterusespecially if it happens after menopauseYour doctor must find out the cause of the bleeding so that he or she can recommend the proper treatmentTaking estrogens without visiting your doctor can cause you serious harm if your vaginal bleeding is caused by cancer of the uterus.

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In patients with pre-existing hypertriglyceridemiaestrogen therapy may be associated with elevations of plasma triglycerides leading to pancreatitis and other complications.

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