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The following adverse reactions are included in more detail in the WARNINGS AND PRECAUTIONS section of the label:
Digoxin increases the strength and efficiency of heart contractionsand is useful in the treatment of heart failure and control the rate and rhythm of the heartIt is extracted from the leaves of a plant called digitalis lanataDigoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzymeATPasethat controls movement of calciumsodiumand potassium into heart muscleCalcium controls the force of contractionInhibiting ATPase increases calcium in heart muscle and therefore increases the force of heart contractionsDigoxin also slows electrical conduction between the atria and the ventricles of the heart and is useful in treating abnormally rapid atrial rhythms such as atrial fibrillationatrial flutterand atrial tachycardiaAbnormally rapid atrial rhythms can be caused by heart attacksexcessive thyroid hormonesalcoholisminfectionsand many other conditionsDuring rapid atrial rhythmselectrical signals from the atria cause rapid contractions of the ventriclesRapid ventricular contractions are inefficient in pumping blood containing oxygen and nutrients to the bodycausing symptoms of weaknessshortness of breathdizzinessand even chest painDigoxin alleviates these symptoms by blocking the electrical conduction between the atria and ventriclesthus slowing ventricular contractionsThe FDA approved digoxin in 1975.
Sensitivity to Lanoxin can be increased by medicines which lower the level of potassium in the bloodThese include:
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conivaptan vaprisol ; digoxin lanoxin, digitalis ; imatinib gleevec ; isoniazid for treating tuberculosis ; an antidepressant such as nefazodone; an antibiotic such as clarithromycin biaxin , erythromycin e.
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