In studies prospectively designed to assess abuse and dependence potential, olanzapine was shown to have acute depressive cns effects but little or no potential of abuse or physical dependence in rats administered oral doses up to 15 times the maximum recommended human daily oral dose 20 mg and rhesus monkeys administered oral doses up to 8 times the maximum recommended human daily oral dose on a mg m 2 basis.
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Adverse Reactions Associated With Discontinuation Of Treatment In Short-TermPlacebo-Controlled Trials.
During pregnancyuse olanzapine with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies doneNeonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for extrapyramidal symptomsEPSor withdrawal symptoms after deliverythese complications vary in severitywith some being self-limited and others requiring ICU support and prolonged hospitalization.
Olanzapine enters breast milkit is not recommended for use while breastfeeding.
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olanzapine versus placebo and haloperidol acute phase results of the north american double-blind olanzapine trial.
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