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Promethazine s antiallergenic properties are likely derived from its histaminergic action, whereas its antiemetic properties are associated with its central anticholinergic effects.

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Promethazine Hydrochloride Tablets USP are contraindicated for children under 2 years of agesee WARNINGS-Black Box Warning and Use in Pediatric Patients

Long-term animal studies have not been performed to assess the carcinogenic potential of promethazinenor are there other animal or human data concerning carcinogenicitymutagenicity or impairment of fertility with this drugPromethazine was nonmutagenic in the Salmonella test system of Ames.

PROMETHAZINE HYDROCHLORIDE TABLETS USP ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE.

Sedating drugs may cause confusion and over-sedation in the elderlyelderly patients generally should be started on low doses of promethazine hydrochloride tablets and observed closely.

Promethazine should not be used in children younger than 2 years because it may cause seriouspossibly fatalslow/shallow breathingWhen using this medication in children 2 years and olderthe lowest effective dosage should be usedand other drugs that affect breathing should be avoidedGet medical help right away if slow/shallow breathing occurs.

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promethazine administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn.

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