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Well controlled studies have demonstrated that doses of hydrochlorothiazide as low as 25 mg given once daily are effective in treating hypertensionbut the dose-response has not been clearly established.

Hydrochlorothiazidea sulfonamidecan cause an idiosyncratic reactionresulting in acute transient myopia and acute angle-closure glaucomaSymptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiationUntreated acute angle-closure glaucoma can lead to permanent vision lossThe primary treatment is to discontinue hydrochlorothiazide as rapidly as possiblePrompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolledRisk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

MAXZIDEtriamterene and hydrochlorothiazideshould not be used in the presence of elevated serum potassium levelsgreater than or equal to 5.5 mEq/literIf hyperkalemia developsthis drug should be discontinued and a thiazide alone should be substituted.

Side effects observed in association with the use of MAXZIDEother combination products containing triamterene/hydrochlorothiazideand products containing triamterene or hydrochlorothiazide include the following:

If your doctor has directed you to use this medicationyour doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for themDo not startstopor change the dosage of any medicine before checking with your doctorhealth care provider or pharmacist first.

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