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Taking wellbutrin during the first trimester of pregnancy has been associated with the development of certain heart defects among newborn infants.

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Information about Wellbutrin.

Do not use bupropion if you have used an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilineor tranylcypromine.

This drug may make you dizzy or affect your coordinationAlcohol or marijuana can make you more dizzy or affect your coordinationDo not driveuse machineryor do anything that needs alertness until you can do it safelyAvoid alcoholic beveragesAlcohol can also increase your risk of seizuresTalk to your doctor if you are using marijuana.

Your dosage is based on your medical condition and response to therapyYour dose may be slowly increased to limit side effects such as sleeplessnessand to decrease the risk of seizuresTo avoid trouble sleepingdo not take this medication too close to bedtimeLet your doctor know if sleeplessness becomes a problem.

You may have a higher risk of seizures if you use certain other medicines while taking Wellbutrin.

AWhen antidepressants or other medicines for mental illnesses are stopped abruptlysymptoms may return and the illness may be harder to treatIn additionwithdrawal symptoms are possibleA review of medical literature showed a report of withdrawal symptoms in a person being treated with WellbutrinbupropionThe symptoms included irritable moodanxietysleeplessnessheadacheand generalized aches and painsTo relieve these symptomsthe doctors restarted bupropion and then slowly tapered the dose down over two to three weeksAccording to the package insertit is recommended that patients gradually reduce the dose of antidepressant rather than stopping the medication abruptlyIf intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatmentthen resuming the previously prescribed dose may be consideredSubsequentlydoctors may continue decreasing the dose but at a more gradual rateFor more specific informationconsult with your doctor or pharmacist for guidance based on your health status and current medicationsparticularly before taking any actionMichelle McDermottPharmD.

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