Celebrex works by stopping the production of cox-2, a natural substance in the body that causes pain and inflammation.
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NSAIDs may diminish the antihypertensive effect of angiotensin converting enzymeACEinhibitorsangiotensin receptor blockersARBsor beta-blockersincluding propranololIn patients who are elderlyvolume-depletedincluding those on diuretic therapyor have renal impairmentco-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal functionincluding possible acute renal failureThese effects are usually reversible.
Advise patients to report symptoms of ulcerations and bleedingincluding epigastric paindyspepsiamelenaand hematemesis to their health care providerIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxisinform patients of the increased risk for and the signs and symptoms of GI bleedingsee WARNINGS AND PRECAUTIONS
Celecoxib has been associated with anaphylactic reactions in patients with and without known hypersensitivity to celecoxib and in patients with aspirin sensitive asthmaCelebrex is a sulfonamide and both NSAIDs and sulfonamides may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible peoplesee CONTRAINDICATIONS and Exacerbation Of Asthma Related To Aspirin Sensitivity
The effects of celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburideketoconazolesee DRUG INTERACTIONSphenytoinand tolbutamide have been studied in vivo and clinically important interactions have not been found.
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