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Interstitial pneumonitis has been reported as part of the postmarketing experienceInterstitial pulmonary fibrosis has been reported in patients receiving high doses of cyclophosphamide over a prolonged period.
Treatment with cyclophosphamide may cause significant suppression of immune responsesSerioussometimes fatalinfections may develop in severely immunosuppressed patientsCyclophosphamide treatment may not be indicatedor should be interruptedor the dose reducedin patients who have or who develop viralbacterialfungalprotozoanor helminthic infections.
Metabolites interfere with malignant cell growth by cross-linking tumor cell DNAdrug does not have specificity for any phase of the cell cyclealso has potent immunosuppressive activity.
Prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplant.
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