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Rapidaccurate diagnosis and treatment in an emergency-room or intensive-care setting are important in order to prevent the potentially life-threatening central nervous system and systemic effects of intrathecal baclofen withdrawalThe suggested treatment for intrathecal baclofen withdrawal is the restoration of intrathecal baclofen at or near the same dosage as before therapy was interruptedHoweverif restoration of intrathecal delivery is delayedtreatment with GABA-ergic agonist drugs such as oral or enteral baclofenor oralenteralor intravenous benzodiazepines may prevent potentially fatal sequelaeOral or enteral baclofen alone should not be relied upon to halt the progression of intrathecal baclofen withdrawal.

Ovarian cysts have been found by palpation in about 4of the multiple sclerosis patients that were treated with Lioresal for up to one yearIn most cases these cysts disappeared spontaneously while patients continued to receive the drugOvarian cysts are estimated to occur spontaneously in approximately 1to 5of the normal female population.

The most frequent1adverse events reported during all clinical trials are shown in the following tableNine patients discontinued long term treatment due to adverse events.

INCIDENCE OF MOST FREQUENT1ADVERSE EVENTS IN PATIENTS WITH SPASTICITY OF CEREBRAL ORIGIN IN PROSPECTIVELY MONITORED CLINICAL TRIALS.

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this tolerance may be treated by gradually reducing lioresal intrathecal dose over a 2 to 4 week period and switching to alternative methods of spasticity management e.