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The pharmacokinetics of cilostazol and its metabolites were similar in subjects with mild hepatic disease as compared to healthy subjects.
No dosage adjustment is necessary in patients with mild hepatic diseaseThere are no data in patients with moderate or severe hepatic impairmentSince cilostazol is extensively metabolised by hepatic enzymesit is contraindicated in patients with moderate or severe hepatic impairment.
The following adverse reactions are discussed in greater detail inother sections of the labeling:
Pletal is indicated for the reduction of symptoms of intermittent claudicationas demonstrated by an increased walking distance.
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