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Long-term use of prochlorperazine can cause a serious movement disorder that may not be reversibleThe longer you take Compazinethe more likely you are to develop this movement disorderThe risk of this side effect is higher in women and older adults.
For Nausea/VomitingI went to the ER with a migraine and I got this through an IVI was totally fine and all happy until this drug hit meI went completely insaneI got claustrophobicI wanted to kill myselfI started twitchingand I got super anxiousThey gave me some Benadryl which helped so they sent me homeOn the way home it happened againand it kept happening all night even after I kept taking BenadrylThe only time I felt not insane was when I was sleeping but I was still having weird dreamsThe next morning I woke up and I was still really anxious but the serious side effects went awayFor 2 more days I still felt anxious and it was the worst thing everEveryone told me this was really rare and I don’t think any of the people there at the ER really knew what was going onThis is a scary drugI just wanted to share my story
Acetylcholinesterase inhibitors may decrease the effectives of prochlorperazineCentrally acting acetylcholinesterase inhibitors may increase the neurotoxic effects of antipsychotic agentsCombining prochlorperazine with alcoholkava kavaCNS depressantsand cannabis may increase the risk of CNS depressant side effectsAntacids may decrease the absorption of prochlorperazineProchlorperazine may cause anticholinergic side effects such as dry mouthconstipationdry eyesdecreased urinary outputand mental confusionCombining agents with similar anticholinergic effects increases the risk of experiencing such adverse eventsProchlorperazine may increase the blood levels of dofetilideTikosynUse of both drugs is not recommendedDeferoxamineDesferalmay increase the risk of experiencing side effects of prochlorperazine treatmentCombination use has resulted in the prolonged loss of consciousnessMetoclopramideReglanmay increase the side effects of antipsychotic agentsCombination use is not recommendedProchlorperazine may increase the CNS depressant effects of orphenadrineNorflexor paraldehydeParalCombination use is not recommendedCombining prochlorperazine and potassium chloride may result in an increase in the ulcerogenic effect of potassium chlorideKlor-ConCombination use is generally not recommendedCombining prochlorperazine with thalidomideThalomidmay increase the risk of experiencing CNS depressant side effectsThis combination is generally not recommended.
This medication may make you sweat lessmaking you more likely to get heat strokeAvoid doing things that may cause you to overheatsuch as hard work or exercise in hot weatheror using hot tubsWhen the weather is hotdrink a lot of fluids and dress lightlyIf you overheatquickly look for a place to cool down and restGet medical help right away if you have a fever that does not go awaymental/mood changesheadacheor dizziness.
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