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Patients taking concomitant co-trimoxazoletrimethoprim/sulfamethoxazolemay be at increased risk for hyperkalaemiasee section 4.4

In patients undergoing major surgery or during anaesthesia with agents that produce hypotensionlisinopril may block angiotensin II formation secondary to compensatory renin releaseIf hypotension occurs and is considered to be due to this mechanismit can be corrected by volume expansion.

You may also need to avoid taking Zestoretic with aliskiren if you have kidney disease.

There is evidence that the concomitant use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren increases the risk of hypotensionhyperkalaemia and decreased renal functionincluding acute renal failureDual blockade of RAAS through the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is therefore not recommendedsee sections 4.5 and 5.1

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