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Naltrexone should not be confused with naloxone, which is used in emergency cases of opioid overdose.

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The naloxone challenge test should not be performed in a patient showing clinical signs or symptoms of opioid withdrawalor in a patient whose urine contains opioidsThe naloxone challenge test may be administered by either the intravenous or subcutaneous routes.

Patients taking REVIA may not benefit from opioid containing medicinessuch as cough and cold preparationsantidiarrheal preparationsand opioid analgesicsIn an emergency situation when opioid analgesia must be administered to a patient receiving REVIAthe amount of opioid required may be greater than usualand the resulting respiratory depression may be deeper and more prolongedsee PRECAUTIONS

Patients should be warned of the risk of hepatic injury and advised to seek medical attention if they experience symptoms of acute hepatitisUse of REVIA should be discontinued in the event of symptoms and/or signs of acute hepatitis.

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