In 28 double-blind, controlled placebo- or active-controlled clinical trials, 11,308 patients with primary hyperlipidemia age range 10 93 years, 48 women, 85 caucasians, 7 blacks, 4 hispanics, 3 asians and elevated ldl-c were treated with atorlip-ez ezetimibe 10 mg day concurrently with or added to on-going statin therapy for a median treatment duration of 8 weeks range 0 to 112 weeks .
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CYP2C19 Inhibitos: Clopidogl is mtabolizd tits activ mtabolit in pat by CYP2C19. Concomitant us ctain dugs that inhibit th activity this nzym sults in ducd plasma concntations th activ mtabolit clopidogl and a duction in platlt inhibition. Th clinical lvanc this intaction is unctain. As a pcaution concomitant us stong modat CYP2C19 inhibitos should b discouagd. Mdicinal poducts that a stong modat CYP2C19 inhibitos includ xampl, ompazol and sompazol, luvoxamin, luoxtin, moclobmid, voiconazol, luconazol, ticlopidin, cabamazpin, and avinz.
Patints with a histoy cnt myocadial inaction (MI), cnt stok, stablishd piphal atial disas, clopidogl has bn shown tduc th at a combind ndpoint nw ischmic stok (atal not), nw MI (atal not), and oth vascula dath.
Oal Anti-coagulants: Th concomitant administation ATOLIP CV with oal anti-coagulants is not commndd sinc it may incas th intnsity blding. Atovastatin had nclinically signiicant ct on pothombin tim whn administd tpatints civing chonic waain tatmnt. Although th administation clopidogl 75 mg p day did not modiy th phamacokintics S-waain (a CYP2C9 substat) Intnational Nomalizd ati(IN) in patints civing long-tm waain thapy, at high concntations in vit, clopidogl inhibits CYP2C9. Co-administation ATOLIP CV with waain incass th isk blding bcaus indpndnt cts clopidogl on hmostasis.
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