Actimmune, avonex, betaseron, intron a, infergen, and others interferon anturane sulfinpyrazone certain medications for hiv aids, such as crixivan indinavir , videx didanosine , or zerit stavudine medications that suppress the immune system, such as cyclosporine neoral and sandimmune , imuran azathioprine , prograf tacrolimus , rheumatrex methotrexate , or rapamune sirolimus probalan probenecid .
Information about Imuran.
Before starting the administration of immunosuppressantsthe prescriber should check to see if the patient has a history of VZVSerologic testing may be useful in determining previous exposurePatients who have no history of exposure should avoid contact with individuals with chickenpox or herpes zosterIf the patient is exposed to VZVspecial care must be taken to avoid patients developing chickenpox or herpes zosterand passive immunisation with varicella-zoster immunoglobulinVZIGmay be considered.
Imuran tablets are used as an immunosuppressant antimetabolite either alone ormore commonlyin combination with other agentsusually corticosteroidsand procedures which influence the immune responseTherapeutic effect may be evident only after weeks or months and can include a steroid-sparing effectthereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids.
It has been suggested that cimetidine and indomethacin may have myelosuppressive effectswhich may be enhanced by concomitant administration of Imuran.
Relief of chronic renal insufficiency by renal transplantation involving the administration of Imuran has been accompanied by increased fertility in both male and female transplant recipients.
It has been suggested that the toxicity of Imuran may be enhanced in the presence of renal insufficiencybut controlled studies have not supported this suggestionNeverthelessit is recommended that the dosages used should be at the lower end of the normal range and that haematological response should be carefully monitoredDosage should be further reduced if haematological toxicity occurs.
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