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CRIXIVAN is not a cure for HIV-1 infection and patients may continue to experience illnesses associated with HIV-1 infectionincluding opportunistic infectionsPatients should remain under the care of a physician when using CRIXIVAN.
See your doctor regularly so that he/she can monitor your healthContinue to practise safer sex and take other precautions so as not to pass HIV on to other people.
When HIV becomes resistant to one drug in a classit sometimes becomes resistant to other drugs in that classThis is called cross-resistanceFeel free to talk with your doctor about your current and future treatment optionsTo help you decide what these future therapies might beat some point your doctor can have a small sample of your blood analysed using resistance testingShould HIV in your body become resistant to indinavir your doctorwith the help of resistance testingcan help put together a new treatment regimen for you.
Table 9Established and Other Potentially Significant Drug InteractionsAlteration in Dose or Regimen May Be Recommended Based on Drug Interaction Studies or Predicted InteractionSee also CLINICAL PHARMACOLOGY for magnitude of interactionWARNINGS and DOSAGE AND ADMINISTRATION
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inhibition of cyp3a4 by indinavir may increase the plasma concentrations of simeprevir, resulting in adverse effects.
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