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Pump Implantation Patients should be infection-free prior to pump implantation because the presence of infection may increase the risk of surgical complicationsMoreovera systemic infection may complicate dosing.
A dose-related increase in incidence of ovarian cysts and a less marked increase in enlarged and/or hemorrhagic adrenal glands was observed in female rats treated chronically with Lioresal.
Intrathecal massCases of intrathecal mass at the tip of the implanted catheter have been reportedmost of them involving pharmacy compounded analgesic admixturesThe most frequent symptoms associated with intrathecal mass are1decreased therapeutic responseworsening spasticityreturn of spasticity when previously well controlledwithdrawal symptomspoor response to escalating dosesor frequent or large dosage increases2pain3neurological deficit/dysfunctionClinicians should monitor patients on intraspinal therapy carefully for any new neurological signs or symptomsIn patients with new neurological signs or symptoms suggestive of an intrathecal massconsider a neurosurgical consultationsince many of the symptoms of inflammatory mass are not unlike the symptoms experienced by patients with severe spasticity from their diseaseIn some casesperformance of an imaging procedure may be appropriate to confirm or rule-out the diagnosis of an intrathecal mass.
Symptoms of LIORESAL INTRATHECAL OverdoseDrowsinesslightheadednessdizzinesssomnolencerespiratory depressionhypothermiaseizuresrostral progression of hypotonia and loss of consciousness progressing to coma of up to 72 hrdurationIn most cases reportedcoma was reversible without sequelae after drug was discontinuedSymptoms of LIORESAL INTRATHECAL overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.
Strict aseptic technique in filling is required to avoid bacterial contamination and serious infectionA period of observation appropriate to the clinical situation should follow each refill or manipulation of the drug reservoir.
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