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Do not use trazodone if you have taken an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidphenelzinerasagilineselegilineand tranylcypromineAfter you stop taking trazodoneyou must wait at least 14 days before you start taking an MAOI.

Patients with major depressive disorderMDDboth adult and pediatricmay experience worsening of their depression and/or the emergence of suicidal ideation and behaviorsuicidalityor unusual changes in behaviorwhether or not they are taking antidepressant medicationsand this risk may persist until significant remission occursThere has been a long-standing concern that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patientsAntidepressants increased the risk of suicidal thinking and behaviorsuicidalityin short-term studies in children and adolescents with Major Depressive DisorderMDDand other psychiatric disorders.

The efficacy of the extended-release tablets for the maintenance treatment of MDD has not been evaluatedWhile there is no body of evidence available to answer the question of how long a patient treated with trazodone extended-release tablets should continue the drugit is generally recommended that treatment be continued for several months after an initial responsePatients should be maintained on the lowest effective dose and be periodically reassessed to determine the continued need for maintenance treatment.

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it should be noted that desyrel trazodone hydrochloride is not approved for use in treating bipolar depression.