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A migraineon the other handis also a type of a headache which results in an acute throbbing sensation in one part of your headUsuallymigraine headaches are highly painfulMigraine pain makes it difficult for a person to carry out his/her daily tasksSymptoms or signs associated with migraine attacks are:
Angio-oedemae.gfacial oedematongue swelling and pharyngeal oedemamay occur in patients treated with triptanssuch as rizatriptanIf angio-oedema of the tongue or pharynx occursthe patient should be placed under medical supervision until the symptoms have resolvedTreatment should promptly be discontinued and replaced by an agent belonging to another class of drugs.
Current theories on the aetiology of migraine headache suggest that the symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal systemThe therapeutic activity of rizatriptan in migraine can most likely be attributed to agonist effects at 5-HT 1B/1D receptors on the extracerebralintracranial blood vesselswhich become dilated during a migraine attackand on nerve terminals in the trigeminal systemActivation of these receptors results in cranial vessel constrictioninhibition of neuropeptide release and reduced transmission in trigeminal pain pathways.
If you experience migraine attacks less frequentlythese medicines may give you quick relief:
Ergot-containing drugs have been reported to cause prolonged vasospastic reactionsBecause there is a theoretical basis that these effects may be additiveuse of ergotamine-containing or ergot-type medicationslike dihydroergotamine or methysergideand rizatriptan within 24 hours is contraindicatedDue to an additive effectthe concomitant use of rizatriptan and ergotamine/ergot derivativesincluding methysergideincreases the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contraindicated.
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