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AffiliationDepartments of Health Sciences and GeneticsUniversity of LeicesterLeicesterUnited Kingdom.

It should be noted that whilein theorytwo different sequences could have the same checksum valuethe likelihood that this would happen is extremely low.

The SERPINA1 gene provides instructions for making a protein called alpha-1 antitrypsinwhich is a type of serine protease inhibitorserpinSerpins help control several types of chemical reactions by blockinginhibitingthe activity of certain enzymesAlpha-1 antitrypsin prevents the digestive enzyme trypsin from breaking down proteins until trypsin reaches the intestinesAlpha-1 antitrypsin also inhibits other enzymesincluding a powerful enzyme called neutrophil elastase that is released from white blood cells to fight infection.

Descriptions and acknowledgments of individual studies contributing to the SNP association analyses with FEV1.

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