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Combination therapy with nevirapine is not a curative treatment of patients infected with HIV-1patients may continue to experience illnesses associated with advanced HIV-1 infectionincluding opportunistic infections.

Coadministration with drugsegCYP inducerswhere significant decreases in nevirapine plasma concentrations may occurwhich may result in loss of virologic response and possible resistance and cross-resistance to other NNRTIs.

The dose should not be increased to the maintenance dose until any rash has clearedIf the patient cannot switch to the full dose within four weeks of starting Viramunealternative treatments should be sought.

In case of severe skinliveror hypersensitivity reactionnevirapine must be discontinued permanently.

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