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It should also be noted that Zyloprim is generally better tolerated if taken following mealsA fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral orpreferablyslightly alkaline urine are desirable.

Allopurinol can decrease the number of blood cells in your body that make blood clot and that help you fight infectionswhich can make it easier for you to bleed from an injury or get sick when exposed to others who are illYou should avoid being around people who are sick or have infections while taking this medicine.

Allopurinol is an inhibitor of xanthine oxidasea substance in the body that is responsible for the product of uric acidIt is used to prevent goutkidney stonesand kidney damage caused by uric acidIt is also used to reduce the levels of uric acid in the blood that occur because of blood disorders associated with cancer such as leukemias and lymphomas.

Do not give this medication to anyone elseeven if they have the same symptoms as you doIt can be harmful for people to take this medication if their doctor has not prescribed it.

The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS

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