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Rare occurrences of neuroleptic malignant syndromeNMShave been reportedThis potentially fatal syndrome is comprised of the symptom complex of hyperthermiaaltered consciousnessmuscular rigidityand autonomic dysfunctionsee WARNINGS

Stop taking metoclopramide and call your doctor at once if you have any of these SIGNS OF A SERIOUS MOVEMENT DISORDERwhich may occur within the first 2 days of treatment:

A few cases of rashurticariaor bronchospasmespecially in patients with a history of asthmaRarelyangioneurotic edemaincluding glossal or laryngeal edema.

Metoclopramide undergoes minimal hepatic metabolismexcept for simple conjugationIts safe use has been described in patients with advanced liver disease whose renal function was normal.

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