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A large nci-sponsored randomized clinical trial called the breast cancer prevention trial found that tamoxifen, taken for 5 years, reduced the risk of developing invasive breast cancer by about 50 in postmenopausal women who were at increased risk 12 .

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You may get a mild skin rash while taking tamoxifenTell your doctor or nurse if this happens.

You may put on weight when you are taking tamoxifenEating healthily and being more physically active can help to keep you to a healthy weightYour doctor or nurse can give you more advice.

Hormones are substances produced naturally in the bodyThey act as chemical messengers and help control the activity of cells and organsHormonal therapies are drugs that interfere with the way hormones are made or how they work in the body.

If you need to go into hospital for any reasonalways tell the doctors and nurses that you are taking tamoxifenExplain you are taking a hormonal therapy drug that no one should stop or restart without checking with your cancer doctor firstTell them the name of your cancer doctor and their contact details so they can ask for advice.

You may feel tiredsleepy or feel you have no energy when you start taking tamoxifenTry to pace yourself until this improvesAim for a balance between having enough rest and being physically activeDoing exerciselike going for regular short walkswill help you to feel less tired.

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006 for time to tumor progression; objective tumor response rates were similar for arimidex and tamoxifen.

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