Be sure to mention any of the following atazanavir reyataz ; benzodiazepines such as midazolam versed and triazolam halcion ; beta blockers such as atenolol tenormin , labetalol trandate , metoprolol lopressor, toprol xl , nadolol corgard , and propranolol inderal ; buspirone buspar ; carbamazepine carbatrol, epitol, tegretol ; cimetidine tagamet ; cyclosporine gengraf, neoral, sandimmune ; digoxin lanoxin, lanoxicaps ; lovastatin altoprev, mevacor, in advicor ; quinidine quinidex ; and rifampin rifadin, in rifamate, in rifater, rimactane .
Information about Tegretol.
In additionTegretol causesor would be expected to causedecreased levels of the following drugsfor which monitoring of concentrations or dosage adjustment may be necessaryacetaminophenalbendazolealprazolamaprepitantbuprenorphonebupropioncitalopramclonazepamclozapinecorticosteroidse.gprednisolonedexamethasonecyclosporinedicumaroldihydropyridine calcium channel blockerse.gfelodipinedoxycyclineethosuximideeverolimushaloperidolimatinibitraconazolelamotriginelevothyroxinemethadonemethsuximidemianserinmidazolamolanzapineoral and other hormonal contraceptivesoxcarbazepinepaliperidonephensuximidephenytoinpraziquantelprotease inhibitorsrisperidonesertralinesirolimustadalafiltheophyllinetiagabinetopiramatetramadoltrazodonetricyclic antidepressantse.gimipramineamitriptylinenortriptylinevalproatewarfarinziprasidonezonisamide.
When carbamazepine is added to aripiprazolethe aripiprazole dose should be doubledAdditional dose increases should be based on clinical evaluationIf carbamazepine is later withdrawnthe aripiprazole dose should be reducedWhen carbamazepine is used with tacrolimusmonitoring of tacrolimus blood concentrations and appropriate dosage adjustments are recommendedThe use of concomitant strong CYP3A4 inducers such as carbamazepine should be avoided with temsirolimusIf patients must be coadministered carbamazepine with temsirolimusan adjustment of temsirolimus dosage should be consideredThe use of carbamazepine with lapatinib should generally be avoidedIf carbamazepine is started in a patient already taking lapatinibthe dose of lapatinib should be gradually titrated upIf carbamazepine is discontinuedthe lapatinib dose should be reducedConcomitant use of carbamazepine with nefazodone results in plasma concentrations of nefazodone and its active metabolite insufficient to achieve a therapeutic effectCoadministration of carbamazepine with nefazodone is contraindicatedsee CONTRAINDICATIONSMonitor concentrations of valproate when Tegretol is introduced or withdrawn in patients using valproic acid.
Thyroid function tests have been reported to show decreased values with Tegretol administered alone.
Nauseavomitinggastric distress and abdominal paindiarrheaconstipationanorexiaand dryness of the mouth and pharynxincluding glossitis and stomatitis.
Carbamazepine mustthereforebe considered to be carcinogenic in Sprague-Dawley ratsBacterial and mammalian mutagenicity studies using carbamazepine produced negative resultsThe significance of these findings relative to the use of carbamazepine in humans isat presentunknown.
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