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Hypothalamic-pituitary-adrenalHPAaxis suppressionCushing’s syndromeand intracranial hypertension have been reported in pediatric patients receiving topical corticosteroidsManifestations of adrenal suppression in pediatric patients include linear growth retardationdelayed weight gainlow plasma cortisol levelsand absence of response to ACTH stimulationManifestations of intracranial hypertension include bulging fontanellesheadachesand bilateral papilledema.
It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milkSystemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infantNeverthelesscaution should be exercised when topical corticosteroids are administered to a nursing woman.
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehiclethe integrity of the epidermal barrierand the use of occlusive dressings.
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