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If you use esomeprazole for longer than 3 yearsyou could develop a vitamin B-12 deficiencyTalk to your doctor about how to manage this condition if you develop it.

This medicine can cause diarrheawhich may be a sign of a new infectionIf you have diarrhea that is watery or bloodycall your doctor before using anti-diarrhea medicine.

Daily treatment with any acid-suppressing medications over a long period of timee.glonger than 3 yearsmay lead to malabsorption of cyanocobalaminvitamin B-12caused by hypoor achlorhydriaRare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literatureThis diagnosis should be considered if clinical symptoms consistent with cyanocobalamin deficiency are observed.

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nexium esomeprazole is in a class of drug called a proton pump inhibitor.