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Adequate studies have not been performed in animals to determine whether fludrocortisone acetate has carcinogenic or mutagenic activity or whether it affects fertility in males or females.
Prolonged use of corticosteroids may produce posterior subcapsular cataractsglaucoma with possible damage to the optic nervesand may enhance the establishment of secondary ocular infections due to fungi or viruses.
There is an enhanced corticosteroid effect in patients with hypothyroidism and in those with cirrhosis.
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